Promethazine with Codeine Oral Solution must be made use of with caution in patients with bone-marrow despair. Leukopenia and agranulocytosis are described, typically when promethazine has become used in Affiliation with other regarded marrow-poisonous brokers.
Daily life-threatening respiratory melancholy and death have occurred in children who obtained codeine. Codeine is issue to variability in metabolism centered on CYP2D6 genotype (described beneath), which can cause an increased publicity towards the Lively metabolite morphine. Dependent on submit-internet marketing stories, children younger than 12 yrs old seem like more vulnerable to the respiratory depressant outcomes of codeine, especially if there are actually chance factors for respiratory melancholy.
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This is simply not an entire listing of probable Unwanted side effects. In case you notice other Unwanted side effects not stated earlier mentioned, Speak to your medical professional or pharmacist.
Retain a list of every one of the products you employ (which includes prescription/nonprescription prescription drugs and herbal goods) and share it with the physician and pharmacist. Will not start, prevent, or alter the dosage of any medicines without having your health care provider's approval.
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A possibly lethal symptom elaborate occasionally called Neuroleptic Malignant Syndrome (NMS) continues to be reported in association with promethazine HCl by itself or together with antipsychotic medicine.
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Dosing errors may end up in accidental overdose and Loss of life. To lessen the potential risk of overdose and respiratory depression, be certain that the dose of Promethazine with Codeine Oral Solution is communicated Evidently and dispensed correctly [see Dosage and Administration ( 2.1) ]. Advise individuals to always use an click here correct milliliter measuring system when measuring and administering Promethazine with Codeine Oral Resolution. Tell patients that domestic teaspoon is not website an accurate measuring gadget and this sort of use may lead to overdosage and really serious adverse reactions [see ]. For prescriptions in which a measuring machine is not presented, a pharmacist can more info offer an proper calibrated measuring product and can provide instructions for measuring the correct dose.
If this SPL consists of inactivated NDCs shown because of the FDA initiated compliance action, They are going to more info be specified as a result.
-Doses better than 60 mg have not been revealed to improve discomfort reduction and they are connected to a heightened incidence of adverse outcomes.
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Talk to your pharmacist exactly where to Find a drug just take-back again disposal application. If there's no just take-back again application, mix the leftover drugs with cat litter or coffee grounds inside a sealed plastic bag throw the bag while in the trash.
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